Universal Information Software Technology for Non-Oriented Mixed Forests

Cybernetics and Systems Analysis - A new information software technology has been created, which is implemented in a software package and is destined to perform a wide, easily supplemented set of...     

Polysorbate identity and quantity dictate the extensional flow properties of protein-excipient solutions

While protein medications are promising for treatment of cancer and autoimmune diseases, challenges persist in terms of development and injection stability of high-concentration formulations. Here, the extensional flow properties of protein-excipient solutions are examined via dripping-onto-substrate extensional rheology, using a model ovalbumin (OVA) protein and biocompatible excipients polysorbate 20 (PS20) and 80 (PS80). Despite similar PS structures, differences in extensional flow are observed based on PS identity in two regimes: at moderate total concentrations where surface tension differences drive changes in extensional flow behavior, and at small PS:OVA ratios, which impact the onset of weakly elastic flow behavior. Undesirable elasticity is observed in ultra-concentrated formulations, independent of PS identity; higher PS contents are required to observe these effects than in analogous polymeric excipient solutions. These studies reveal novel extensional flow behaviors in protein-excipient solutions, and provide a straightforward methodology for assessing the extensional flow stability of new protein-excipient formulations.     

Hydrogenation of CO2 to Hydrocarbons over Zirconia-Supported Cobalt Catalyst Promoted with Potassium

Catalysis Letters - The purpose of this study was to investigate the promotive effect of potassium on the catalytic performance and properties of Co/ZrO2 catalysts during hydrogenation of CO2 to...     

A hybrid GA and PSO optimized approach for heart-disease prediction based on random forest

Multimedia Tools and Applications - Nowadays, heart diseases are significantly contributing to deaths all over the world. Thus, heart-disease prediction has garnered considerable attention in the...     

Modernization of Air Supply Unit for Oxidation Towers Used in Bitumen Production

Chemical and Petroleum Engineering - The hydrodynamics of oxidation towers used for bitumen production were studied using a model tower having transparent walls. Experiments were carried out in two...     

Increasing Probability of Detecting Acoustic Emission Sources Using Artificial Neural Networks

Russian Journal of Nondestructive Testing - We study the possibilities of reducing the location error of acoustic emission (AE) sources for cases where AE sources are located near AE receiving...     

Influence of Variable Machining Conditions on the Precision in CNC Plunge Grinding: Predictive Analysis by a Digital Twin

Russian Engineering Research - A system for predicting the machining error for a batch of parts in CNC wheel grinding is described; the system takes the influence of technological variables into...